Using one of the new Mac Pros, we used 2 DisplayPort to VGA adapters and one TripleHead2Go with three outputs running out of the Mac Pro. Our video guys built the video in After Effects, outputted it as a single .mov file and we played it back on 5 screens in the house. All 5 outputs ran into our Barco FSN Switcher. Our video guys built the video to span all 5 screens. Ran very well. Our setup is a little weird with some screens in portrait mode and some in landscape mode, but it all worked out. The crowd loved it.
